Restoring Immune Balance at the Root
From landmark discoveries to immune tolerance reset — building therapies that re-educate, not suppress, the immune system.
Landmark Discoveries Behind Our Science
TangGene’s platform is built on decades of pioneering immunology, led by world-class scientists:
Together, these discoveries create the foundation for TangGene’s immune tolerance reset — moving autoimmune therapy from broad suppression to precision cures. See related Publications.
Our Approach
Tissue-specific, Q/E-restricted CD8⁺ Treg
Autoimmune diseases arise when the immune system attacks the body’s own tissues. Current therapies suppress immunity broadly, often with severe side effects and requiring lifelong treatment.
TangGene’s approach is designed to efficiently mobilize tissue-specific, Q/E-restricted CD8⁺ Tregs directly within patients, restoring immune tolerance at its source and offering the potential for durable remission and lasting cures.
Our Nanoparticle Platform
Targeted Immune Tolerance Reset via CD8⁺ Treg
PLGA Nanoparticle with APIs and targeting molecules
Targeting dendritic cells (DCs) specifically
Controlled and sustained release
Programming DCs for Q/E epitope presentation
Tissue-specific Q/E-restricted CD8⁺ Treg stimulation and expansion.
Safety: FDA-approved nanoparticle materials, precise targeting, and no broad suppression.
Efficacy: Durable memory Tregs and lasting remission
Accessibility: Scalable, off-the-shelf, and cost-effective
Curative Potential: Root-cause reset, halt progression, and prevent relapse.
Why It Matters
Solving the Key Challenges of Existing Therapies
The Future of Autoimmune Therapy
TangGene’s science represents a new class of precision immunotherapy — pioneering immune reset to bring lasting remission and renewed hope to millions worldwide.
